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The intracellular targets of action of metronidazole on anaerobes are largely mysterious. The five-nitro group of metronidazole is lessened by metabolically Energetic anaerobes, and research have shown the lessened type of the drug interacts with ‑bacterial DNA.
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Utilization of cimetidine with oral metronidazole may well prolong the 50 %-daily life and decrease plasma clearance of metronidazole.
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Oral metronidazole is reported to potentiate the anticoagulant outcome of coumarin and warfarin, leading to a prolongation of prothrombin time. Use warning when prescribing for individuals who will be acquiring anticoagulant treatment method.
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